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  Indian J Med Microbiol
 

Figure 1: Histopathology of the kidney biopsy and the immunofluorescent image of a 42-year-old non-diabetic, non-hypertensive male presented with generalized body swelling and frothing of urine for 3 months. A: Light microscopy (H&E stain, 100×) shows three enlarged glomeruli showing uniform diffuse and global glomerular basement membrane thickening. Adjacent tubulointerstitial compartment reveals moderate interstitial fibrosis and tubular atrophy with presence of epithelioid granuloma surrounded by lymphoplasmacytic cells. Inset shows high power view (Periodic acid Schiff stain, 200×). B: Light microscopy (JMS stain, 200×) shows portion of a glomerulus with uniform diffuse and global glomerular basement membrane thickening with appreciable spikes (blue arrow). Adjacent tubulointerstitial compartment reveals presence of epithelioid granuloma with Langhans' giant cells (yellow arrows). Inset reveals presence of acid fast bacilli (ZN stain, 1 000×). C: Fluorescein isothiocyanate labelled immunoglobulin G, A and M, complement component 3 and 1q, kappa and lambda; 200×) using frozen specimen-fine granular positivity along GBM in IgG (4+), C3c (1+), C1q (trace), kappa (2+) and lambda (3+).

Figure 1: Histopathology of the kidney biopsy and the immunofluorescent image of a 42-year-old non-diabetic, non-hypertensive male presented with generalized body swelling and frothing of urine for 3 months. A: Light microscopy (H&E stain, 100×) shows three enlarged glomeruli showing uniform diffuse and global glomerular basement membrane thickening. Adjacent tubulointerstitial compartment reveals moderate interstitial fibrosis and tubular atrophy with presence of epithelioid granuloma surrounded by lymphoplasmacytic cells. Inset shows high power view (Periodic acid Schiff stain, 200×). B: Light microscopy (JMS stain, 200×) shows portion of a glomerulus with uniform diffuse and global glomerular basement membrane thickening with appreciable spikes (blue arrow). Adjacent tubulointerstitial compartment reveals presence of epithelioid granuloma with Langhans' giant cells (yellow arrows). Inset reveals presence of acid fast bacilli (ZN stain, 1 000×). C: Fluorescein isothiocyanate labelled immunoglobulin G, A and M, complement component 3 and 1q, kappa and lambda; 200×) using frozen specimen-fine granular positivity along GBM in IgG (4+), C3c (1+), C1q (trace), kappa (2+) and lambda (3+).