Figure 7: Cartoon depiction of the 4HDG structure coloured according to the conservation score calculated by ConSurf web tool. The colour scale ranges from cyan (high sequence variability) to dark red (high sequence conservation). White is the “neutrality” colour. GTP is displayed with stick models. Positions subject to selective pressure are represented as stick models and labelled accordingly. All of them occur in highly variable positions of the RdRp domain of Flavivirus NS5 proteins.