Figure 5: Therapeutic effect of P. daemia on histological alterations induced by ATDs. A: Liver of control rat showed normal arrangement of hepatocytes, central vein (CV), sinusoidal space (SS) and rounded nucleus (N) (400×). B: ATDs intoxicated group showed enlarged hepatocytes with loss of cordial arrangement, disturbed sinusoidal space, vacuolation (V), inflammatory cell infiltration and a few hepatocytes with centrally located nucleus (400×). C):Therapy of P. daemia at 100 mg/kg showed mild hepatocyte vacuolization (V) and relatively less alteration in central vein and sinusoidal space (400 ×). D: Treatment of P. daemia at 200 mg/kg showed significant protection with negligible inflammation in hepatocytes and rounded nucleus (400×). E: P. daemia at 400 mg/kg treated group depicted rounded nucleus, cordially arranged hepatocytes and well-formed central vein (400×). F: Silymarin at 50 mg/kg treated group showed normal and cordially arranged hepatocytes around central vein (400×).