Asian Pacific Journal of Tropical Medicine

REVIEW ARTICLE
Year
: 2022  |  Volume : 15  |  Issue : 1  |  Page : 7--16

Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review


Nur Ellene Mat Luwi1, Suhana Ahmad1, Ahmad Suhaimi Nurfatihah Azlyna1, Asyikin Nordin1, Maria Elena Sarmiento2, Armando Acosta2, Mohd Nor Norazmi2, Vuk Uskoković3, Rohimah Mohamud1, Ramlah Kadir1 
1 Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2 School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3 Department of Mechanical Engineering, San Diego State University, Campanile Dr. 5500, San Diego 921982; TardigradeNano LLC, Irvine, CA 92604, USA

Correspondence Address:
Ramlah Kadir
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan
Malaysia

Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis remains an important health problem that requires the development of an effective vaccine, especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin (BCG) one developed 100 years ago. This review focuses on the different applications of liposomes toward achieving this goal. Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.


How to cite this article:
Luwi NE, Ahmad S, Azlyna AS, Nordin A, Sarmiento ME, Acosta A, Norazmi MN, Uskoković V, Mohamud R, Kadir R. Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review.Asian Pac J Trop Med 2022;15:7-16


How to cite this URL:
Luwi NE, Ahmad S, Azlyna AS, Nordin A, Sarmiento ME, Acosta A, Norazmi MN, Uskoković V, Mohamud R, Kadir R. Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review. Asian Pac J Trop Med [serial online] 2022 [cited 2022 Nov 26 ];15:7-16
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=1;spage=7;epage=16;aulast=Luwi;type=0