Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 15  |  Issue : 12  |  Page : 551--557

Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul


Berkin Berk Akbeyaz1, AyŞe Karaaslan2, Ceren Çetin2, Mehmet Tolga Köle3, Zeynep AltaŞ4, Yasemin Akın3 
1 Department of Pediatrics, University of Health Sciences, Kartal Dr. Lütfi Kirdar City Hospital, Pediatric Hematology and Oncology Istanbul, Turkey
2 Department of Pediatric Infectious Diseases, University of Health Sciences, Kartal Dr. Lütfi Kirdar City Hospital, Istanbul, Turkey
3 Department of Pediatrics, University of Health Sciences, Kartal Dr. Lütfi Kirdar City Hospital, Istanbul, Turkey
4 Department of Public Health, Marmara University, Istanbul, Turkey

Correspondence Address:
Berkin Berk Akbeyaz
Department of Pediatrics, University of Health Sciences, Kartal Dr. Lütfi Kirdar City Hospital, Pediatric Hematology and Oncology Istanbul, Turkey
Turkey

Objective: To examine the effect of the COVID-19 virus, especially the Omicron variant, on hematological parameters of hospitalized pediatric patients during the COVID-19 pandemic. Methods: Medical records of pediatric COVID-19 patients hospitalized at Kartal Dr. Lütfi Kirdar City Hospital in Istanbul, Turkey, between March 2020 and May 2022 were retrospectively reviewed to analyze data regarding demographics, SARS-CoV-2 infection polymerase chain reaction (PCR) test results, reverse-transcriptase (RT)-PCR for other respiratory agents, duration of hospital stay, and hematological and biochemical laboratory findings. Results: Out of 467 children with a confirmed diagnosis of SARS-CoV-2 infection, 94 (20.1%) had Omicron infection and 373 (79.9%) were infected with other variants; the Omicron group had younger patients than the remaining samples (P<0.001). The most frequent clinical symptoms in all children were cough (53.5%) and fever (32.3%), followed by vomiting (20.8%). Lung involvement in the Omicron group (10.6%) was significantly lower than in the remaining samples (29.8%) (P<0.001). Hemoglobin and lymphocyte levels were lower in the Omicron-infected group (both P<0.001), while prothrombin time, activated partial thromboplastin time, international normalized ratio, and D-dimer levels were significantly higher in this group (P<0.001, P<0.001, P<0.001, and P=0.023, respectively). In terms of lung involvement, those with lung involvement were significantly older (P<0.001). Conclusions: Although lung involvement was less common with Omicron infection, this group had greater hematological system involvement, such as anemia, lymphopenia, D-dimer elevation, and coagulation disorders.


How to cite this article:
Akbeyaz BB, Karaaslan A, Çetin C, Köle MT, AltaŞ Z, Akın Y. Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul.Asian Pac J Trop Med 2022;15:551-557


How to cite this URL:
Akbeyaz BB, Karaaslan A, Çetin C, Köle MT, AltaŞ Z, Akın Y. Hematological profile of COVID-19 infected children before and after the spread of the Omicron variant in Istanbul. Asian Pac J Trop Med [serial online] 2022 [cited 2023 Feb 7 ];15:551-557
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2022;volume=15;issue=12;spage=551;epage=557;aulast=Akbeyaz;type=0