ORIGINAL ARTICLE
Year : 2020 | Volume
: 13 | Issue : 11 | Page : 487--493
Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis
Huong TT Vu1, Azumi Ishizaki2, Quynh T Nguyen3, Huyen N Nguyen1, Hoi T Le1, Kinh V Nguyen1, Hiroshi Ichimura2
1 National Hospital for Tropical Disease, Hanoi, Vietnam
2 Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Japan
3 National Hospital for Tropical Disease, Hanoi, Vietnam; Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University, Japan
Correspondence Address:
Azumi Ishizaki
Department of Viral Infection and International Health, Graduate School of Medical Sciences, Kanazawa University
Japan
Objective: To evaluate the outcomes of generic direct-acting antiviral treatments for chronic hepatitis C in Vietnam.
Methods: The medical records of 522 patients (median 45 years; Female, 25.3%) with chronic hepatitis C treated at a tertiary hospital in northern Vietnam in 2016 were retrospectively reviewed.
Results: Female patients were significantly older than male patients (median 52, IQR 41-59 vs. 43 years, IQR: 39-55; P<0.001). Among 522 patients, 49.4% were infected with hepatitis C virus (HCV) genotype 6, followed by 1a (19.0%), 1b (13.0%), and 3 (5.9%). Co-infection with hepatitis B virus or human immunodeficiency virus was noted in 5.8% and 3.1% of patients, respectively. Patients were treated with ledipasvir/sofosbuvir with or without ribavirin (70.9%), sofosbuvir/pegylated-interferon + ribavirin (13.2%), daclatasvir/ sofosbuvir with or without ribavirin (12.5%), or sofosbuvir/ribavirin (3.4%), and 96.4% (n=503) completed the direct-acting antiviral treatment. No patient discontinued treatment due to adverse event(s). A sustained virologic response 12 weeks after the end of the treatment (SVR12) was evaluated in 62.6% of patients. Overall sustained virologic response 12 weeks after the end of the treatment was 98.7% regardless of HCV genotypes or direct-acting antiviral regimens. The severity of liver stiffness was significantly decreased from 10.2 to 6.3 kilopascals measured by transient elastography by the treatment (P<0.001). Among patients who completed the direct-acting antiviral treatment, 17.7% returned for further follow-ups after SVR12.
Conclusions: In Vietnam, the current generic direct-acting antiviral treatment for chronic hepatitis C was effective regardless of HCV genotypes and direct-acting antiviral regimens with the attenuation of liver stiffness. It is feasible to implement direct-acting antiviral treatment to cure chronic hepatitis C patients at any liver fibrosis stages in Vietnam.
How to cite this article:
Vu HT, Ishizaki A, Nguyen QT, Nguyen HN, Le HT, Nguyen KV, Ichimura H. Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis.Asian Pac J Trop Med 2020;13:487-493
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How to cite this URL:
Vu HT, Ishizaki A, Nguyen QT, Nguyen HN, Le HT, Nguyen KV, Ichimura H. Clinical outcomes of patients with chronic hepatitis C after generic direct-acting antiviral treatments in Vietnam: A retrospective analysis. Asian Pac J Trop Med [serial online] 2020 [cited 2023 Apr 2 ];13:487-493
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=487;epage=493;aulast=Vu;type=0 |
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