Asian Pacific Journal of Tropical Medicine

REVIEW ARTICLE
Year
: 2020  |  Volume : 13  |  Issue : 11  |  Page : 477--486

Convalescent plasma: A potential therapeutic option for COVID-19 patients


Swee Li Ng1, Tsuey Ning Soon2, Wei Hsum Yap2, Kai Bin Liew3, Ya Chee Lim4, Long Chiau Ming4, Yin-Quan Tang2, Bey Hing Goh5 
1 Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia
2 School of Biosciences, Faculty of Medical and Health Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia
3 Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, Malaysia
4 PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam
5 Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

Correspondence Address:
Bey Hing Goh
Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

Yin-Quan Tang
School of Biosciences, Faculty of Medical and Health Sciences, Taylor's University, Subang Jaya, Selangor
Malaysia

The new coronavirus disease (COVID-19) outbreak has challenged us to take unprecedented steps to bring this pandemic under control. In view of the urgency of this situation, convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current pandemic. This is mainly due to the fact that convalescent plasma has been studied in a few case series with promising outcomes. In addition, on-going large clinical trials aimed to further evaluate the effectiveness, safety, and optimal dosage, duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising results. Therefore, this article aims to provide an overview of possible mechanisms of actions of convalescent plasma, its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.


How to cite this article:
Ng SL, Soon TN, Yap WH, Liew KB, Lim YC, Ming LC, Tang YQ, Goh BH. Convalescent plasma: A potential therapeutic option for COVID-19 patients.Asian Pac J Trop Med 2020;13:477-486


How to cite this URL:
Ng SL, Soon TN, Yap WH, Liew KB, Lim YC, Ming LC, Tang YQ, Goh BH. Convalescent plasma: A potential therapeutic option for COVID-19 patients. Asian Pac J Trop Med [serial online] 2020 [cited 2022 May 25 ];13:477-486
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=11;spage=477;epage=486;aulast=Ng;type=0