Asian Pacific Journal of Tropical Medicine

REVIEW ARTICLE
Year
: 2019  |  Volume : 12  |  Issue : 1  |  Page : 8--13

Antibiotic resistance of Neisseria species in Iran: A systematic review and meta-analysis


Farzad Khademi1, Amirhossein Sahebkar2 
1 Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2 Biotechnology Research Center, Pharmaceutical Technology Institute; Neurogenic Inflammation Research Center; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Farzad Khademi
Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil
Iran

Objective: To estimate the prevalence of antibiotic resistance of Neisseria species in Iran. Methods: A systematic and electronic search using relevant keywords in major national and international databases was performed until 6th July, 2018 in order to find studies reporting the prevalence of antibiotic resistance of Neisseria species in Iran. Results: A total of nine studies were found to be eligible based on predefined inclusion and exclusion criteria. Our analysis indicated that the prevalence of Neisseria gonorrhoeae resistance to different antibiotics was as follows: 66.9% to penicillin, 59.1% to ciprofloxacin, 11.1% to ceftriaxone, 21.6% to spectinomycin, 13.8% to cefixime, 82.4% to co-trimoxazole, 52.7% to tetracycline, 29.9% to gentamicin, 87.5% to ampicillin, 11.1% to azithromycin, 2.2% to chloramphenicol, 50.1% to cefepime and 50.0% to vancomycin. Antimicrobial resistance rates of Neisseria meningitidis was as follows: 30.0% to penicillin, 33.3% to amoxicillin, 33.3% to cephalexin, 55.6% to ampicillin and 0.0% to ciprofloxacin, ceftriaxone, cefotaxime, amikacin, co-trimoxazole, gentamicin, kanamycin, chloramphenicol and ceftizoxime. Conclusion: Neisseria gonorrhoeae and Neisseria meningitidis isolates of Iran show resistance to different types of antibiotics. Therefore, care should be exercised for the use of penicillin, ciprofloxacin, co-trimoxazole, tetracycline, gentamicin, ampicillin, cefepime and vancomycin for gonococcal infections, and also with respect to the use of penicillin, amoxicillin, ampicillin and cephalexin for meningococcal infections in Iran.


How to cite this article:
Khademi F, Sahebkar A. Antibiotic resistance of Neisseria species in Iran: A systematic review and meta-analysis.Asian Pac J Trop Med 2019;12:8-13


How to cite this URL:
Khademi F, Sahebkar A. Antibiotic resistance of Neisseria species in Iran: A systematic review and meta-analysis. Asian Pac J Trop Med [serial online] 2019 [cited 2023 Feb 6 ];12:8-13
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=1;spage=8;epage=13;aulast=Khademi;type=0