Asian Pacific Journal of Tropical Medicine

REVIEW ARTICLE
Year
: 2018  |  Volume : 11  |  Issue : 1  |  Page : 1--8

An updated systematic review of Zika virus-linked complications


Braira Wahid1, Amjad Ali2, Muhammad Waqar1, Muhammad Idrees3 
1 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan
2 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
3 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore; Hazara University, Mansehra, Pakistan

Correspondence Address:
Amjad Ali
Centre for Applied Molecular Biology, University of the Punjab, Lahore-53700
Pakistan

Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library. Only those research articles, case studies, case-control studies, case-cohort studies, cross-sectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis, meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.


How to cite this article:
Wahid B, Ali A, Waqar M, Idrees M. An updated systematic review of Zika virus-linked complications.Asian Pac J Trop Med 2018;11:1-8


How to cite this URL:
Wahid B, Ali A, Waqar M, Idrees M. An updated systematic review of Zika virus-linked complications. Asian Pac J Trop Med [serial online] 2018 [cited 2022 Dec 9 ];11:1-8
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=1;spage=1;epage=8;aulast=Wahid;type=0