| ORIGINAL ARTICLE |
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| Year : 2023 | Volume
: 16
| Issue : 2 | Page : 65-71 |
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Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study
Govind R Patel1, Indu Thanvi2, Mohammad Nadeem2, Rahul Kanwaria2
1 Department of Clinical Hematology, Dr. SN Medical College, Jodhpur, Rajasthan, India
2 Department of General Medicine, Dr. SN Medical College, Jodhpur, Rajasthan, India
Correspondence Address:
Govind R Patel
Department of Clinical Hematology, Dr. SN Medical College, Jodhpur, Rajasthan
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/1995-7645.370149
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Objective: To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with dengue.
Methods: This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June 2022. Coagulation tests including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer were performed. Patients were monitored for bleeding manifestations.
Results: Coagulation abnormalities were reported in 42.8% of the patients. Overall, prolonged aPTT was the most common coagulation abnormality (40.8%), followed by low fibrinogen (38.7%), raised D-dimer (31.2%), raised INR (26.0%) and prolonged PT (19.2%). Bleeding manifestations were present in 19.9% patients. PT, INR, aPTT and D-dimer levels were significantly higher (P<0.01) and fibrinogen level was significantly lower (P<0.001) in patients with bleeding compared to patients without bleeding. Patients with bleeding had a significantly higher rate of all coagulation abnormalities than patients without bleeding (P<0.01).
Conclusions: Patients with bleeding showed a significantly higher frequency of coagulation abnormalities compared to patients without bleeding. Patients with dengue should be assessed for coagulation abnormalities.
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