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Year : 2022  |  Volume : 15  |  Issue : 3  |  Page : 135-142

Larvicidal activity of the pericarp extract of Garcinia mangostana against dengue vector Aedes aegypti in Sri Lanka

1 Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
2 Department of Zoology and Environmental Management, Faculty of Science, University of Kelaniya, Dalugama, Sri Lanka
3 Department of Biosystems Engineering, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makadura, Sri Lanka
4 Department of Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

Correspondence Address:
Nayana Gunathilaka
Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama
Sri Lanka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1995-7645.340573

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Objective: To assess the larvicidal activity of mangosteen (Garcinia mangostana) against larval stages of Aedes aegypti mosquitoes. Methods: A crude extract was prepared in ethanol from powdered mangosteen pericarps. A concentration gradient (0.01-4.92 g/ L) was prepared from the stock solution. Seven batches of 25 third instar larvae of Aedes aegypti were used for larval bioassays. Larval mortality rates were observed after one and 24 hours. Cholesterol and total lipid contents in 20 randomly selected dead larvae at each trial were assessed by colorimetric method. The experimental setup was repeated five times. The General Linear Model and Probit analysis were used to evaluate the relationship of mortality with cholesterol level, total lipid level and cholesterol to total lipid ratio. Results: The percentage mortalities significantly varied with different concentrations (F732=385.737; P<0.001). The LC50 and LC99 values were (0.041 ± 0.006) g/L and (10.616 ± 1.758) g/L, respectively after 24-hours. There was no mortality recorded within the one-hour exposure time. Only the cholesterol content (F524=173.245; P<0.001) in larvae exposed to different concentrations denoted a significantly decreasing trend within 24hour exposure. Larvae that were exposed to the lowest concentration (0.55 g/L) showed a higher cholesterol level (22.67 ± 1.33) μg. Conclusions: The Garcinia mangostana extract acts as an effective sterol carrier protein inhibitor that inhibits cholesterol uptake in Aedes aegypti mosquitoes. Hence, it could be explored for use as a key source for the development of an environment-friendly plant-based larvicide.

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