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REVIEW ARTICLE
Year : 2022  |  Volume : 15  |  Issue : 1  |  Page : 7-16

Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review


1 Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2 School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3 Department of Mechanical Engineering, San Diego State University, Campanile Dr. 5500, San Diego 921982; TardigradeNano LLC, Irvine, CA 92604, USA

Correspondence Address:
Ramlah Kadir
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan
Malaysia
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Source of Support: This study was supported by Fundamental Research Grant Scheme (FRGS/1/2018/SKK08/USM/03/1), Ministry of Higher Education (Malaysia) and Long.term Research Grant Scheme (LRGS/1/2015/ USM/01/1/1), Ministry of Higher Education (Malaysia), Conflict of Interest: None


DOI: 10.4103/1995-7645.332806

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Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis remains an important health problem that requires the development of an effective vaccine, especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin (BCG) one developed 100 years ago. This review focuses on the different applications of liposomes toward achieving this goal. Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.


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