Neglected scrub typhus: An updated review with a focus on omics technologies

Dixit Sharma; Ankita Sharma; Birbal Singh; Sunil Kumar; Shailender Kumar Verma

doi:10.4103/1995-7645.364003

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Year : 2022 \| Volume : 15 \| Issue : 12 \| Page : 531-541

Neglected scrub typhus: An updated review with a focus on omics technologies Dixit Sharma¹, Ankita Sharma², Birbal Singh³, Sunil Kumar⁴, Shailender Kumar Verma² ¹ Centre for Computational Biology and Bioinformatics; Department of Animal Science, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India ² Centre for Computational Biology and Bioinformatics, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India ³ ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India ⁴ Department of Animal Science, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India Correspondence Address: Dixit Sharma Centre for Computational Biology and Bioinformatics; Department of Animal Science, School of Life Sciences, Central University of Himachal Pradesh, Kangra 176206, India India Source of Support: None, Conflict of Interest: None DOI: 10.4103/1995-7645.364003

Scrub typhus is a neglected disease and one of the most serious health problems in the Asia-Pacific region. The disease is caused by an obligate intracellular bacteria Orientia tsutsugamushi, which is transmitted by chigger bites or larval mite bites. Scrub typhus is a threat to billions of people worldwide causing different health complications and acute encephalitis in infants and growing children. The disease causes multiple organ failure and mortality rates may reach up to 70% due to a lack of appropriate healthcare. Currently available genome and proteome databases, and bioinformatics methods are valuable tools to develop novel therapeutics to curb the pathogen. This review discusses the state-of-the-art of information about Orientia tsutsugamushi-mediated scrub typhus and delineates the role of omics technologies to develop drugs against the pathogen. The role of proteome-wide in silico approaches for the identification of therapeutic targets is also highlighted.



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Orientia tsutsugamushi; Scrub typhus; Therapeutic targets; Omics technologies; Drug discovery

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