Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review

Ana Carolina Marinho Monteiro Lima; Greice Carolina Santos da Silva; Fernanda Khouri Barreto; Filipe Ferreira de Almeida Rego; Luana Leandro Gois; Luciane Amorim Santos

doi:10.4103/1995-7645.321609

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Year : 2021 \| Volume : 14 \| Issue : 8 \| Page : 333-340

Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review Ana Carolina Marinho Monteiro Lima¹, Greice Carolina Santos da Silva¹, Fernanda Khouri Barreto², Filipe Ferreira de Almeida Rego¹, Luana Leandro Gois³, Luciane Amorim Santos⁴ ¹ Catholic University of Salvador, Salvador, Bahia, Brazil ² Multidisciplinary Institute in Health, Federal University of Bahia, Vitoria da Conquista, Bahia, Brazil ³ Catholic University of Salvador; Bahia School of Medicine and Public Health, Salvador, Bahia, Brazil ⁴ Catholic University of Salvador, Salvador; Multidisciplinary Institute in Health, Federal University of Bahia, Vitoria da Conquista; Postgraduate Program in Health Sciences, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador, Bahia, Brazil Correspondence Address: Luciane Amorim Santos Catholic University of Salvador, Salvador; Multidisciplinary Institute in Health, Federal University of Bahia, Vitoria da Conquista; Postgraduate Program in Health Sciences, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador, Bahia Brazil Source of Support: This research was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (426196/2018-0). ACMML was supported by a scholarship from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (127049/2019-3 and 115208/2020-8), Conflict of Interest: None DOI: 10.4103/1995-7645.321609

Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the progression of HAM/TSP. This review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 mRNAs and/or viral proteins (TAX and HBZ) with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/ TSP development. This systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject descriptors. After screening, six articles were included in this review. The studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP, which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy donors. This systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/ TSP development.



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HTLV-1; HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP); FOXp3; HBZ; TAX

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