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Table of Contents
Year : 2020  |  Volume : 13  |  Issue : 6  |  Page : 242-246

The 2019 novel coronavirus disease (COVID-19) pandemic: A zoonotic prospective

1 Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal 700126, India
2 Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do, Republic of Korea
3 Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Republic of Korea

Date of Submission17-Mar-2020
Date of Decision23-Mar-2020
Date of Acceptance24-Mar-2020
Date of Web Publication03-Apr-2020

Correspondence Address:
Chiranjib Chakraborty
Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal 700126
Sang-Soo Lee
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do
Republic of Korea
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1995-7645.281613

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus (CoV), has recently emerged as a significant pathogen for humans and the cause for the recent outbreak of the 2019 novel coronavirus disease (COVID-19) throughout the globe. For developing any preventive measure, an understanding of the zoonotic pattern for this virus is a necessity. We should have a clear knowledge of its reservoir host, its distribution pattern and spreading routes. Information about zoonotic reservoirs and its transmission among them can help to understand the COVID-19 outbreaks. In this article, we discuss about the bats as the zoonotic reservoir of several CoV strains, co-existence of bats and CoV/viruses, the sequence similarity of SARS-CoV-2 with bat SARS-like CoV, the probable source of the origin of SARS-CoV-2 strain and COVID-19 outbreak, intermediate host of CoVs and SARS-CoV-2, human to human transmission and the possibility to maintain the zoonotic barriers. Our knowledge about the zoonotic reservoir of SARS-CoV-2 and its transmission ability may help develop the preventive measures and control for the future outbreak of CoV.

Keywords: SARS-CoV-2; COVID-19; Coronavirus; Zoonotic reservoir

How to cite this article:
Chakraborty C, Sharma AR, Bhattacharya M, Sharma G, Lee SS. The 2019 novel coronavirus disease (COVID-19) pandemic: A zoonotic prospective. Asian Pac J Trop Med 2020;13:242-6

How to cite this URL:
Chakraborty C, Sharma AR, Bhattacharya M, Sharma G, Lee SS. The 2019 novel coronavirus disease (COVID-19) pandemic: A zoonotic prospective. Asian Pac J Trop Med [serial online] 2020 [cited 2023 Jan 30];13:242-6. Available from:

Chiranjib Chakraborty, Ashish Ranjan Sharma. Authors contributed equally to this work.

  1. Introduction Top

A recent outbreak of severe respiratory illness has occurred in Wuhan, China, making Wuhan as the central point of global attention. Patients with pneumonia of unknown etiology in Wuhan were first notified to WHO in China office on 31 December 2019. At that time, the causative agent was unknown. On 9th January, the Chinese Centers for Disease Control and Prevention reported that a strain of coronavirus (CoV) that is distantly associated with the severe acute respiratory syndrome (SARS)-CoV monophyletic group might be the causative agent of the 2019 novel coronavirus disease (COVID-19). Later on, it was established that a novel type of CoV caused the outbreak and was named as SARS-CoV-2[1],[2]. According to a recent report of WHO, till 16th March 2020 more than 167 511 cases of COVID-19 were reported and more than 6 606 deaths are confirmed, suggesting a medical emergency to control this virus.

SARS-CoV-2 outbreak is closely associated with the SARS-CoV and Middle East respiratory syndrome CoV (MERS-CoV) disease as it causes similar symptoms[3]. Previously, in 2002 and 2003, SARS-CoV caused SARS outbreaks in Guangdong Province, Chinaļ4j and in 2012, MERS-CoV caused MERS- outbreak in the Middle East[5]. So, there are three significant CoV outbreaks which are (i) current SARS-CoV-2 outbreak spread throughout the world; (ii) SARS-CoV caused the SARS outbreak in China in 2002 and 2003; (iii) MERS-CoV caused MERS- outbreak in the Middle East in 2012. The recent SARS-CoV-2 outbreak is the biggest outbreak among these and has already spread throughout the world.

It is very important to understand the reservoir host for CoV, its distribution, and spreading routes [Figure 1]. Knowledge about the zoonotic reservoirs is necessary to prevent and control future CoV outbreaks. Here, we talk about the bats as the zoonotic reservoir, coexistence of bats and CoV, the sequence similarity of SARS-CoV-2 with other CoV, the probable source of the origin of SARS-CoV-2 strain, intermediate host of CoVs and SARS-CoV-2, human to human transmission etc.
Figure 1: Transmission line of SARS-COV-2.

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  2. Bat: The zoonotic reservoir of several CoV strains Top

Bats, a unique mammal with flying ability, are the zoonotic reservoirs or natural hosts of several CoVs such as SARS-CoV, MERS-CoV, etc. Other than CoVs, bats are the natural reservoir of various other deadly viruses, for instance, Hendra virus, Ebola virus, Nipah virus, and Marburg viruses [Table 1][6],[7],[8]. More than 200 viruses have been found associated with bats, and probably most of them are RNA viruses[9]. Bat is also called the primary host of these viruses including SARS-CoV-2 as they act as a natural reservoir. It has been observed that the reservoir of the SARS-like CoV is bats, belonging to the genus RhinolophusPAOJ.
Table 1: Various significant features of the primary host of SARS-COV-2, bat (general and immunological features).

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Among bat genera, six genera are important, which are Cynopterus, Rousettus, Nystalus, Myotis, Miniopteru, and Rhinolophus. More than 1 100 different species have been reported for bats[11]. Among these different species of bats, horseshoe bats [genus Rhinolophus (R.)] is the reservoir of the SARS-like-CoVs. Some important species of this bat genus are R. pearsoni, R. macrotis, R. pussilus, and R. ferrumequinum. These genera are the host of the CoV and have been confirmed by the serologic or PCR analysis[12]. In 2002 and 2003, SARS-CoV was initially identified in China. Then, it was found that bats were acting as primary hosts of that outbreak in China. The outbreak was associated with the wildlife meat industry[9]. MERS-CoV, which is the lineage of beta-CoVs (β-CoVs), is also associated with the bat CoV (BatCoVs)[13]. Several scientists have demonstrated that MERS-CoV might also be of bat origin either from Saudi Arabiaļ[14] or Africaļ[15]. However, it is still a mystery that how MERS-CoV got transferred from bats to the camels. For several years, camels have been acted as a zoonotic reservoir for MERS-CoV[16]. However, after the CoV outbreak, a broad sampling was performed using bats and was rigorously studied to understand the route of the CoV outbreak. Similarly, the bats were also studied as a zoonotic reservoir for Nipah and Hendra viruses[17]. Many studies describe that infected bat transmitted the virus to the recipient host, which then acted as an intermediate host. From the intermediate host, the virus may have got transmitted to humans. Some possibilities are also there that the virus got transmitted directly from the bats to humans[9]. Bats can fly and migrate to more than 1 000km and it may permit the bat to spread different diseases in vast areas. At the same time, they may acquire new microorganisms as a reservoirĮ[18].

  3. Bat and CoV/viruses co-existence Top

Bats are the zoonotic reservoir of CoV and several viruses. It has been noted that bats usually harbor viruses and demonstrates no clinical symptoms. More than millions of years, bats and viruses have been co-existing and co-evolving. The strong evolved immune mechanism of the bats has helped them to harbor viruses without any clinical symptoms[19]. It has been observed that one of the effects or molecules of the primary innate immunity is the interferon and it has been found to play a significant role in the controlling mechanism of viral replication. In bats, different types of interferon have been recognized such as Type I interferon and Type III interferon[20]. The evolved immune mechanisms of bats permit the viruses for virus-host relationships. They may have a faster evolution of genes related to innate immunity and this may cause the superior antiviral phenotype of bats[21]. Taken together, viruses have reached a stable co-existing equilibrium with each other.

  4. SARS-CoV-2, a member of β CoV subfamily, has sequence similarity with bat SARS-like CoV Top

As per the classification of the International Committee on Taxonomy of Viruses, CoVs are associated with the family Coronaviridae, subfamily Coronavirinae and order Nidovirales. Based on the genomic structures and phylogenetic relationships, the subfamily is divided into four genera which are alpha coronavirus (α-CoVs), β-CoVs, gamma coronavirus (γ-CoVs), and delta coronavirus δ-CoVs)[22]. The SARS- CoV-2 is a member of the β-CoV subfamily. According to Zhu et al., SARS-CoV-2 has 86.9% genome sequence likeness to bat SARS-like CoV (bat-SL-CoVZC45, GenBank: MG772933.1) genome[23]. It has been also noted that several α-CoV or β-CoV species were found only in bats. Thus, bats are probably the main natural reservoirs of α-CoV or β-CoV[24].

  5. The probable source of the origin of COVID-19 outbreak Top

The source of the origin of COVID-19 is still unidentified. However, there may be an epidemiological connection with the Huanan wholesale seafood market, where the live animals are also traded, including snakes, birds, marmots, and bats[23], suggesting the possibility of animal associated transmission. Some Chinese researchers explored the epidemiological data with the 41 SARS-CoV-2 patients who have taken admission to a Wuhan hospital. The researcher found that among them, 27 patients (66%) had a contact history with the Wuhan Huanan seafood market where live wild animals or slaughtered wild animals were sold for food consumptionļ25j. Although, it was previously reported that MERSr-CoVs and SARSr-CoVs were originated from the bats[22]. The scientists are currently searching for the source of origin of SARS-CoV-2, including probable transitional animal vectors. Some researchers suspect that SARS-CoV-2 has a phylogenetic relation with SARS-CoV, bat SARS-like CoV, etc. which were discovered in humans, bat (mammals) or other wild animals[23]. Conversely, mammals are infected only either by α-CoV or β-CoV. Although γ-CoV and δ-CoV are known to affect birds, a few of them can affect mammals [Table 2][26]. However, it is of utmost importance to understand and determine the origin of this ongoing pandemic. This information might help us to cut off the source of the origin of this outbreak from the transmission line.
Table 2: Important CoV strains and their primary host, intermediate host, symptoms of infection.

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  6. Intermediate host of CoV and SARS-CoV-2 Top

The intermediate host is an animal that plays a significant role in the transmission of the virus from natural hosts to others. The intermediate hosts may be domestic animals and these animals themselves might suffer diseases caused by bat-borne or closely related CoV. Swine acute diarrhea syndrome coronavirus was transmitted from bats to pigs[27]. The intermediate hosts of the different CoVs are camelids, cows, camels, civets, pigs, etc. However, the intermediate hosts for SARS- CoV-2 strain are not properly clear and have not been specified yet[28].

  7. Human to human transmission of SARS-CoV-2 Top

Human to human transmission of SARS-CoV-2 has been already reported by several scientists[29-33j. Viruses can spread very fast, irrespective of the borders of the countries. This novel virus can move from a country to another country through the host. Air travel is being one of the main routes of the global spread of this virus. Several infected patients have been confirmed in other provinces in China, which confirms that the virus has no boundaries and is moving from Wuhan to other provinces of China. Several exported instances of this virus are also noted from China to other countries such as Thailand, Japan, South Korea, Macau, Malaysia, Australia, France, Canada, Vietnam, Nepal, India, the USA, Iran, and Italy.

Human to human transmission of SARS-CoV-2 got amplified due to the new-year celebration time in China. It was a significant cause for the movement of the human population resulting in the primary outbreak and spreading of the SARS-CoV-2. Human to the human transmission may occur in several ways such as through the sneeze, droplets from the cough, surfaces of public transport and other public places[28].

Human CoV disease can cause mild respiratory and intestinal infections in animals as well as humans. This virus was believed to cause mild infection to humans, until the epidemic of SARS in 2002 and 2003 in Guangdong Province, China[4],[6].

  8. Maintaining the zoonotic barriersU Top

After two outbreaks of SARS-CoV in 2002 and 2003 and one outbreak of MERS-CoV in 2012, this CoV outbreak is a recurrence of the previous incident with a novel strain, and all these of the CoV strains are probably of bat origin. However, our question is, can scientists prevent any CoV outbreak to maintain the barriers between zoonotic reservoirs? Some studies demonstrated that several factors are responsible for the barriers between the zoonotic reservoirs such as spike protein features[34] and proteolytic cleavage of the primary barrierĮ35j. However, more efforts are required to understand the specific features of zoonotic barriers.

  9. Conclusions Top

At the whole-genome level, it was found that SARS-CoV-2 is closer to bat SARS-like CoV (bat-SL-CoVZXC21 and bat-SL-CoVZC45). The typical evolutionary rate for CoV is approximately calculated as 10-4 nucleotide substitutions for every site each year[36]. Therefore, it was decided that the SARS-CoV-2 is a fresh lineage of β-CoV, which is intimately connected to bat SARS-related CoV[37]. With the increase of human population and societal changes, human-wildlife contact may increase. It may cause zoonotic viruses, including SARS-CoV-2, prone to the infection to humans as well as animals. However, more studies are obligatory to enhance our knowledge about zoonotic aspects of SARS-CoV-2 and its spread out from the zoonotic reservoir. Our knowledge about the zoonotic reservoir may provide the answer about the preventive measure for any future outbreak.

Conflict of interest statement

No potential conflict of interest was reported by the author(s).


This study was supported by Hallym University Research Fund and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1A2B4012944 & NRF-2020R1C1C1008694).

Authors’ contributions

CC designed the manuscript. CC and ARS wrote the manuscript. Both MB and GS contributed to the final version of the manuscript. SSL edited the manuscript.

  References Top

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506.  Back to cited text no. 1
Bhattacharya M, Ranjan SA, Patra P, Ghosh P, Sharma G, Chandra PB, et al. Development of epitope-based peptide vaccine against novel Coronavirus 2019 (SARS-COV-2): Immunoinformatics approach. J Med Virol 2020; doi: 10.1002/jmv.25736.  Back to cited text no. 2
Liu SL, Saif L. Emerging viruses without borders: The Wuhan coronavirus. Viruses MDPI 2020; 12: 130. doi: 10.3390/v12020130.  Back to cited text no. 3
Zhong N, Zheng B, Li Y, Poon L, Xie Z, Chan K, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003. Lancet 2003; 362: 1353-1358.  Back to cited text no. 4
Zaki AM, Van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367: 1814-1820.  Back to cited text no. 5
Han HJ, Wen HL, Zhou CM, Chen FF, Luo LM, Liu JW, et al. Bats as reservoirs of severe emerging infectious diseases. Virus Res 2015; 205: 1-6.  Back to cited text no. 6
Li W, Shi Z, Yu M, Ren W, Smith C, Epstein JH, et al. Bats are natural reservoirs of SARS-like coronaviruses. Science 2005; 310(5748): 676-679.  Back to cited text no. 7
Hu B, Ge X, Wang LF, Shi Z. Bat origin of human coronaviruses.Virol J 2015; 12(1): 221.  Back to cited text no. 8
Allocati N, Petrucci A, Di Giovanni P, Masulli M, Di Ilio C, De Laurenzi V. Bat-man disease transmission: Zoonotic pathogens from wildlife reservoirs to human populations. Cell Death Discov 2016; 2(1): 1-8.  Back to cited text no. 9
Lau SK, Woo PC, Li KS, Huang Y, Tsoi HW, Wong BH, et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci USA 2005; 102(39): 14040-14045.  Back to cited text no. 10
Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. Bats: Important reservoir hosts of emerging viruses. Clin Microbiol Rev 2006; 19(3): 531545.  Back to cited text no. 11
Wang LF, Shi Z, Zhang S, Field H, Daszak P, Eaton BT. Review of bats and SARS. Emerg Infect Dis 2006; 12(12): 1834.  Back to cited text no. 12
Wang Q, Qi J, Yuan Y, Xuan Y, Han P, Wan Y, et al. Bat origins of MERS- CoV supported by bat coronavirus HKU4 usage of human receptor CD26. Cell Host Microbe 2014; 16(3): 328-337.  Back to cited text no. 13
Memish ZA, Mishra N, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, et al. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerg Infect Dis 2013; 19(11): 1819.  Back to cited text no. 14
Ithete NL, Stoffberg S, Corman VM, Cottontail VM, Richards LR, Schoeman MC, et al. Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa. Emerg Infect Dis 2013; 19(10): 1697.  Back to cited text no. 15
Banerjee A, Kulcsar K, Misra V, Frieman M, Mossman K. Bats and coronaviruses. Viruses 2019; 11(1): 41.  Back to cited text no. 16
Plowright RK, Eby P, Hudson PJ, Smith IL, Westcott D, Bryden WL, et al. Ecological dynamics of emerging bat virus spillover. Proc Biol Sci 2015; 282(1798): 20142124. doi: 10.1098/rspb.2014.2124.  Back to cited text no. 17
McGuire LP, Fenton MB, Guglielmo CG. Phenotypic flexibility in migrating bats: Seasonal variation in body composition, organ sizes and fatty acid profiles. J Exp Biol 2013; 216(5): 800-808.  Back to cited text no. 18
Banerjee A, Baker ML, Kulcsar K, Misra V, Plowright R, Mossman K. Novel insights into immune systems of bats. Front Immunol 2020; 11: 26.  Back to cited text no. 19
Subudhi S, Rapin N, Misra V. Immune system modulation and viral persistence in bats: Understanding viral spillover. Viruses 2019; 11(2): 192.  Back to cited text no. 20
Wynne JW, Wang LF. Bats and viruses: Friend or foe? PLoS Pathog 2013; 9(10). doi: 10.1371/journal.ppat.1003651.  Back to cited text no. 21
Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 2019; 17(3): 181-192.  Back to cited text no. 22
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; doi: 10.1056/NEJMoa2001017.  Back to cited text no. 23
Woo PC, Lau SK, Lam CS, Lau CC, Tsang AK, Lau JH, et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J Virol 2012; 86(7): 3995-4008.  Back to cited text no. 24
Xu Y. Unveiling the origin and transmission of 2019-nCoV. Trends Microbiol 2020; doi: 10.1016/j.tim.2020.02.001.  Back to cited text no. 25
Ji W, Wang W, Zhao X, Zai J, Li X. Homologous recombination within the spike glycoprotein of the newly identified coronavirus 2019-nCoV may boost cross-species transmission from snake to human. J Med Virol 2020; doi: 10.1002/jmv.25682.  Back to cited text no. 26
Zhou L, Li QN, Su JN, Chen GH, Wu ZX, Luo Y, et al. The re-emerging of SADS-CoV infection in pig herds in Southern China. Transbound Emerg Dis 2019; 66(5): 2180-2183.  Back to cited text no. 27
Ahmad T, Khan M, Musa TH, Nasir S, Hui J, Bonilla-Aldana DK, et al. COVID-19: Zoonotic aspects. Travel Med Infect Dis 2020: 101607. doi: 10.1016/j.tmaid.2020.101607.  Back to cited text no. 28
Peiris JS, Yuen KY, Osterhaus AD, Stöhr K. The severe acute respiratory syndrome. N Engl J Med 2003; 349(25): 2431-2441.  Back to cited text no. 29
Ralph R, Lew J, Zeng T, Francis M, Xue B, Roux M, et al. 2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel- related cases, and vaccine readiness. J Infect Dev Ctries 2020; 14(1): 3-17.  Back to cited text no. 30
Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents 2020; 55(3): 105924. doi: 10.1016/j.ijantimicag.2020.105924.  Back to cited text no. 31
Riou J, Althaus CL. Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020; Euro Surveill 2020; 25(4). doi: 10.2807/1560-7917. ES.2020.25.4.2000058.  Back to cited text no. 32
Li X, Zai J, Wang X, Li Y. Potential of large ‘first generation’human- to-human transmission of 2019-nCoV J Med Virol 2020; doi: 10.1002/ jmv.25693.  Back to cited text no. 33
Lu G, Wang Q, Gao GF. Bat-to-human: Spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends Microbiol 2015; 23(8): 468-478.  Back to cited text no. 34
Menachery VD, Dinnon KH, Yount BL, McAnarney ET, Gralinski LE, Hale A, et al. Trypsin treatment unlocks barrier for zoonotic bat coronavirus infection. J Virol 2020; 94(5). doi: 10.1128/JVI.01774-19.  Back to cited text no. 35
Su S, Wong G, Shi W, Liu J, Lai AC, Zhou J, et al. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol 2016; 24(6): 490-502. doi: 10.1016/j.tim.2016.03.003.  Back to cited text no. 36
Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-273.  Back to cited text no. 37


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22 Covid-19 vaccine, acceptance, and concern of safety from public perspective in the state of Odisha, India
Dibya Sundar Panda,Ranjan Kumar Giri,Anil Kumar Nagarajappa,Sakeenabi Basha
Human Vaccines & Immunotherapeutics. 2021; : 1
[Pubmed] | [DOI]
23 Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?
Kavya Srinivasan, Ashutosh Kumar Pandey, Ashlena Livingston, Sundararajan Venkatesh
Molecular Biomedicine. 2021; 2(1)
[Pubmed] | [DOI]
24 Human menstrual blood-derived stem cells as immunoregulatory therapy in COVID-19: A case report and review of the literature
Juan Lu,Zhong-Yang Xie,Dan-Hua Zhu,Lan-Juan Li
World Journal of Clinical Cases. 2021; 9(7): 1705
[Pubmed] | [DOI]
25 Clinical effectiveness of drugs in hospitalized patients with COVID-19: a systematic review and meta-analysis
Roberto Ariel Abeldaño Zuñiga, Silvia Mercedes Coca, Giuliana Florencia Abeldaño, Ruth Ana María González-Villoria
Therapeutic Advances in Respiratory Disease. 2021; 15: 1753466621
[Pubmed] | [DOI]
26 A survey on COVID-19 vaccine acceptance and concern among Malaysians
S. A. R. Syed Alwi,E. Rafidah,A. Zurraini,O. Juslina,I. B. Brohi,S. Lukas
BMC Public Health. 2021; 21(1)
[Pubmed] | [DOI]
27 Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis
Masoumeh Adhami,Balal Sadeghi,Ali Rezapour,Ali Akbar Haghdoost,Habib MotieGhader
BMC Biotechnology. 2021; 21(1)
[Pubmed] | [DOI]
28 Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines
José Adão Carvalho Nascimento Júnior,Anamaria Mendonça Santos,Rafael Ciro Marques Cavalcante,Lucindo José Quintans-Júnior,Cristiani Isabel Banderó Walker,Lysandro Pinto Borges,Luiza Abrahão Frank,Mairim Russo Serafini
Drug Development and Industrial Pharmacy. 2021; : 1
[Pubmed] | [DOI]
29 How a catastrophic situation turns into an exceptional opportunity: Covid-19 pandemic in Iran and challenges of online education for new English language educators
Parisa Badrkhani
Interactive Learning Environments. 2021; : 1
[Pubmed] | [DOI]
30 Diagnosis For COVID-19: Current Status and Future Prospects
Alamgir Kabir,Rajib Ahmed,Sheikh Muhammad Asher Iqbal,Rasheduzzaman Chowdhury,Ramasamy Paulmurugan,Utkan Demirci,Waseem Asghar
Expert Review of Molecular Diagnostics. 2021;
[Pubmed] | [DOI]
31 Challenges faced in establishing a dedicated 250 bed COVID-19 intensive care unit in a temporary structure
Shalendra Singh,George Cherian Ambooken,Rangraj Setlur,Shamik Kr Paul,Madhuri Kanitkar,Surinder Singh Bhatia,Ratnesh Singh Kanwar
Trends in Anaesthesia and Critical Care. 2021; 36: 9
[Pubmed] | [DOI]
32 Response to: Status of Remdesivir: Not Yet Beyond Question!
Abinit Saha,Ashish Ranjan Sharma,Manojit Bhattacharya,Garima Sharma,Sang-Soo Lee,Chiranjib Chakraborty
Archives of Medical Research. 2021; 52(1): 104
[Pubmed] | [DOI]
33 Are vanadium complexes druggable against the main protease Mpro of SARS-CoV-2? – A computational approach
Thomas Scior,Hassan H. Abdallah,Siti Fatimah Zaharah Mustafa,José Antonio Guevara-García,Dieter Rehder
Inorganica Chimica Acta. 2021; 519: 120287
[Pubmed] | [DOI]
34 Efficacy and Safety of Pegylated Interferon alfa-2b in Moderate COVID-19: A phase II, randomized, controlled, open-label study
Anuja Pandit,Nirav Bhalani,B.L. Shashi Bhushan,Parshottam Koradia,Shweta Gargiya,Vinay Bhomia,Kevinkumar Kansagra
International Journal of Infectious Diseases. 2021;
[Pubmed] | [DOI]
35 Bioinformatics Analysis of SARS-CoV-2 to Approach an Effective Vaccine Candidate Against COVID-19
Seyed Mehdi Sadat,Mohammad Reza Aghadadeghi,Masoume Yousefi,Arezoo Khodaei,Mona Sadat Larijani,Golnaz Bahramali
Molecular Biotechnology. 2021;
[Pubmed] | [DOI]
36 Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude
Lei-Yun Wang,Jia-Jia Cui,Qian-Ying OuYang,Yan Zhan,Yi-Min Wang,Xiang-Yang Xu,Lu-Lu Yu,Hui Yin,Yang Wang,Chen-Hui Luo,Cheng-Xian Guo,Ji-Ye Yin
EPMA Journal. 2021;
[Pubmed] | [DOI]
37 Designing a next generation multi-epitope based peptide vaccine candidate against SARS-CoV-2 using computational approaches
Ratnadeep Saha,Pratik Ghosh,V. L. S. Prasad Burra
3 Biotech. 2021; 11(2)
[Pubmed] | [DOI]
38 Interpretative immune targets and contemporary position for vaccine development against SARS-CoV-2: A systematic review
Nidhi Chauhan,Shringika Soni,Abhinandan Gupta,Mohammad Aslam,Utkarsh Jain
Journal of Medical Virology. 2021; 93(4): 1967
[Pubmed] | [DOI]
39 A comparative study of human betacoronavirus spike proteins: structure, function and therapeutics
Jyoti Verma,Naidu Subbarao
Archives of Virology. 2021;
[Pubmed] | [DOI]
40 In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs
Abhigyan Choudhury,Suprabhat Mukherjee
Journal of Medical Virology. 2020; 92(10): 2105
[Pubmed] | [DOI]
41 TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19
Mohammad Azam Ansari,Qazi Mohammad Sajid Jamal,Suriya Rehman,Ahmad Almatroudi,Mohammad A. Alzohairy,Mohammad N. Alomary,Takshashila Tripathi,Ali H. Alharbi,Syed Farooq Adil,Mujeeb Khan,M. Shaheer Malik
Arabian Journal of Chemistry. 2020; 13(11): 8069
[Pubmed] | [DOI]
42 Immunoinformatics approach to understand molecular interaction between multi-epitopic regions of SARS-CoV-2 spike-protein with TLR4/MD-2 complex
Manojit Bhattacharya,Ashish Ranjan Sharma,Bidyut Mallick,Garima Sharma,Sang-Soo Lee,Chiranjib Chakraborty
Infection, Genetics and Evolution. 2020; 85: 104587
[Pubmed] | [DOI]
43 Design of a multi-epitope vaccine against SARS-CoV-2 using immunoinformatics approach
Samira Sanami,Milad Zandi,Behzad Pourhossein,Gholam-Reza Mobini,Mohsen Safaei,Atena Abed,Pooria Mohammadi Arvejeh,Fatemeh Amini Chermahini,Morteza Alizadeh
International Journal of Biological Macromolecules. 2020; 164: 871
[Pubmed] | [DOI]
44 Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Neeraj Kumar,Damini Sood,Ramesh Chandra
RSC Advances. 2020; 10(59): 35856
[Pubmed] | [DOI]
45 Simulink Modelling For Simulating Intensive Care Mechanical Ventilators
Paolo Tamburrano,Pietro De Palma,Andrew R. Plummer,Elia Distaso,Riccardo Amirante
E3S Web of Conferences. 2020; 197: 07007
[Pubmed] | [DOI]
46 Designing an efficient multi-epitope vaccine displaying interactions with diverse HLA molecules for an efficient humoral and cellular immune response to prevent COVID-19 infection
Soumya Ranjan Mahapatra,Susrita Sahoo,Budheswar Dehury,Vishakha Raina,Shubhransu Patro,Namrata Misra,Mrutyunjay Suar
Expert Review of Vaccines. 2020; 19(9): 871
[Pubmed] | [DOI]
47 Ten challenging questions about SARS-CoV-2 and COVID-19
Majid Teymoori-Rad,Saeed Samadizadeh,Alijan Tabarraei,Abdolvahab Moradi,Mahsa Bataghva Shahbaz,Alireza Tahamtan
Expert Review of Respiratory Medicine. 2020; 14(9): 881
[Pubmed] | [DOI]
48 Covid-19: a comprehensive review of a formidable foe and the road ahead
Arafat Hussain,Suniti Yadav,Vijay Hadda,Tejas M Suri,Pawan Tiwari,Saurabh Mittal,Karan Madan,Anant Mohan
Expert Review of Respiratory Medicine. 2020; 14(9): 869
[Pubmed] | [DOI]
49 Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2
Hong-Zhi Chen,Ling-Li Tang,Xin-Ling Yu,Jie Zhou,Yun-Feng Chang,Xiang Wu
Infectious Diseases of Poverty. 2020; 9(1)
[Pubmed] | [DOI]

Determinants of COVID-19 Vaccine Acceptance in Saudi Arabia: A Web-Based National Survey

Mohammed Al-Mohaithef,Bijaya Kumar Padhi
Journal of Multidisciplinary Healthcare. 2020; Volume 13: 1657
[Pubmed] | [DOI]
51 Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins
José María Díez,Carolina Romero,Júlia Vergara-Alert,Melissa Belló-Perez,Jordi Rodon,José Manuel Honrubia,Joaquim Segalés,Isabel Sola,Luis Enjuanes,Rodrigo Gajardo
Immunotherapy. 2020; 12(17): 1247
[Pubmed] | [DOI]
52 Understanding COVID-19: From Origin to Potential Therapeutics
Muhammad Moazzam,Muhammad Imran Sajid,Hamza Shahid,Jahanzaib Butt,Irfan Bashir,Muhammad Jamshaid,Amir Nasrolahi Shirazi,Rakesh Kumar Tiwari
International Journal of Environmental Research and Public Health. 2020; 17(16): 5904
[Pubmed] | [DOI]
53 Severe Acute Respiratory Syndrome Coronavirus-2 Induces Cytokine Storm and Inflammation During Coronavirus Disease 19: Perspectives and Possible Therapeutic Approaches
Federica Mannino,Alessandra Bitto,Natasha Irrera
Frontiers in Pharmacology. 2020; 11
[Pubmed] | [DOI]


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