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The phytochemical and pharmacological properties of artocarpin from Artocarpus heterophyllus
Nik Nurul Najihah Nik Mat Daud1, Abdi Wira Septama2, Nordin Simbak1, Eldiza Puji Rahmi3
1 Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud 20400, Kuala Terengganu, Terengganu, Malaysia
2 Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314, Indonesia
3 Faculty of Medicine, UPN Veteran, Jl. Rs. Fatmawati, Pondok Labu, Jakarta Selatan, 12450, Indonesia
Correspondence Address:
Abdi Wira Septama
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314
Indonesia
Nordin Simbak
Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud 20400, Kuala Terengganu, Terengganu
Malaysia
 Source of Support: This study was supported by the Ministry of Higher Education
(MOHE) under FRGS grant with vote number RR 237, Conflict of Interest: None  | 6 |
DOI: 10.4103/1995-7645.273567
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Artocarpus heterophyllus Lam. (Moraceae) has been traditionally used in treating various diseases such as diabetes, diarrhea, malarial fever, inflammation, wound healing and other diseases. Since various bioactive compounds have been found in this plant, this review focuses on the phytochemical and pharmacological properties of a potent bioactive compound artocarpin. Despite its various functions, a mechanistic review on this compound has not been reviewed specifically. Here, pharmacological studies in vitro and in vivo on artocarpin are discussed thoroughly stressing on anticancer, antimicrobial, anti-tyrosinase, antioxidant and antiinflammatory aspects of artocarpin. This review would be beneficial for future study to show the competency of natural products for their therapeutic characteristics. |
