| REVIEW ARTICLE |
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| Year : 2019 | Volume
: 12
| Issue : 2 | Page : 49-59 |
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Epidemiological, prevention and control updates of yellow fever outbreak in Brazil
Marli do Carmo Cupertino1, Rebeca Garcia2, Andréia Patrícia Gomes2, Sérgio Oliveira de Paula3, Nicholas Mayers4, Rodrigo Siqueira-Batista1
1 Medical School, Dinâmica College of the Piranga Valley. Ponte Nova; Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Federal University of Viçosa. Minas Gerais, Brazil
2 Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Federal University of Viçosa. Minas Gerais, Brazil
3 Laboratory of Immunovirology, Department of General Biology, Federal University of Viçosa. Minas Gerais, Brazil
4 Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Federal University of Viçosa; Department of Veterinary Medicine, Universidade Federal de Viçosa. Viçosa. Minas Gerais, Brazil
Correspondence Address:
Rodrigo Siqueira-Batista
Laboratory of Epidemiological and Health Computational Methods in Health, 3rd floor, Room 324, University campus, Viçosa, Minas Gerais
Brazil
 Source of Support: None, Conflict of Interest: None  | 6 |
DOI: 10.4103/1995-7645.250837
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Yellow fever is an acute viral disease endemic to tropical countries, like Brazil, where, since the 1940s, has no significant documented outbreaks similar to that observed between 2016/2018 (2 045 confirmed cases and 677 deaths; caused by the sylvatic form). The principal manipulating factors inciting this change were absence of appropriate vaccination campaigns and increased urbanization & population growth in forest areas, with prevalence of the virus in the species inhabiting of these areas. The 2016/2018 outbreaks exhibited incidence in areas with historically low or no yellow fever virus activity, triggering a surge in recorded deaths - mainly in the Southeastern states of Brazil. The Brazilian government aggressively responded, reforming the countries’ prophylactic measures, including vaccine implementation - as of March, 2018, switching from the former double dose regimen of the vaccine, to a single dose protocol, deemed as adequate. Moreover, some states appropriated the fractionated dosage (1/5 of the standard dose), in foresight of potential vaccine shortages. To prevent the uprising of new sylvatic yellow fever cases in Brazil, it’s obligatory the development of effective combative plans, including adaptation of prophylactic measures individually (use of repellents, protective clothing etc. ), applicable vaccination campaigns in every endemic region, to raise awareness to locals and visitors alike. Notwithstanding these preventative strategies, the persistence of cases and the recent outbreaks in Brazil, highlight the possible ineffectiveness of combative measures. Based on these considerations, the objective of this review was to raise more awareness of the epidemiological impact of the disease in Brazil. |
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