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Survival analysis of 198 patients with pancreatic cancer in Hainan, China: A multi-institution prospective study
Zao-Xi Sun1, Yong-Mei Shen2, Zheng-Ke Sun1, Kai Li1, CM Emmanuel1, Yan Yang1, Yong-Jiang Zhou3, Hai-Rong Huang3
1 Department of Surgery, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Longhua District, Hainan Province, 570102, People's Republic of China
2 School of Public Health, Shanxi Medical University, No. 56 Xinjian nan Road, Yingze District, Taiyuan City, Shanxi Province, 030001, People's Republic of China
3 School of Public Health, Hainan Medical University, No. 3 Yixueyuan Road, Longhua District, Hainan Province, 571199, People's Republic of China
Correspondence Address:
Hai-Rong Huang
School of Public Health, Hainan Medical University, No. 3 Yixueyuan Road, Longhua District, Hainan Province, 571199
People's Republic of China
Yan Yang
Department of Laboratory Medicine, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Longhua District, Haikou Hainan Province, 570102
People's Republic of China
Yong-Jiang Zhou
School of Public Health, Hainan Medical University, No. 3 Yixueyuan Road, Longhua District, Hainan Province, 571199
People's Republic of China
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/1995-7645.271977
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Objective: To explore the survival status and prognostic factors of patients with pancreatic cancer in Hainan.
Methods: Clinical data of patients who were diagnosed as pancreatic cancer and visited the First and Second Affiliated Hospital of Hainan Medical University and Haikou People’s Hospital from 2013 to 2017 were collected based on electronic medical records. Basic information was collected by a self-designed questionnaire. Data about admission examinations including blood routine examination, blood biochemistry tests, tumour markers tests, imaging examination and other clinical tests were also collected. The date of follow-up via telephone was 30 June 2018. The survival rate was analyzed by the Kaplan–Meier method and the logrank test. Univariate and multivariate analyses were performed with COX regression model.
Results: A total of 198 patients were included in the study. Kaplan–Meier results showed that the overall survival (OS) in 6 months and 1, 2, 3 and 5 years was 47.4%, 26.8%, 16.4%, 13.2%, and 8.7%, respectively. The median OS was 5.8 months. Log-rank test analysis found that there were significant differences in OS among patients with different age, surgery status, distant metastasis or absolute number of neutrophils, percentage of neutrophils, absolute number of lymphocytes, neutrophil-to-lymphocyte ratio (NLR), CA199 and carcino-embryonic antigen (P<0.1). COX multivariate analysis showed that age, surgical presence, presence or absence of distant metastasis and NLR were significantly associated OS (P<0.05).
Conclusions: Older age, higher NLR and liver or lung metastasis are independent risk factors, while surgical treatment is an independent protective factor for patients with pancreatic cancer.
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