| REVIEW ARTICLE |
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| Year : 2018 | Volume
: 11
| Issue : 1 | Page : 1-8 |
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An updated systematic review of Zika virus-linked complications
Braira Wahid1, Amjad Ali2, Muhammad Waqar1, Muhammad Idrees3
1 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan
2 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
3 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore; Hazara University, Mansehra, Pakistan
Correspondence Address:
Amjad Ali
Centre for Applied Molecular Biology, University of the Punjab, Lahore-53700
Pakistan
 Source of Support: None, Conflict of Interest: None  | 3 |
DOI: 10.4103/1995-7645.223527
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Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library. Only those research articles, case studies, case-control studies, case-cohort studies, cross-sectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis, meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.
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