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Year : 2018  |  Volume : 11  |  Issue : 12  |  Page : 688-692

Can miRNA712_3p be a promising biomarker for early diagnosis of toxoplasmosis?

1 Medical Parasitology Department, Faculty of Medicine, Alexandria University, Egypt
2 Medical Biochemistry Department, Faculty of Medicine, Alexandria University, Egypt
3 Pharmaceutical Chemistry, Faculty of Pharmacy and Drug Manufacturing, Pharos University in Alexandria, Alexandria, Egypt

Correspondence Address:
Nermine Mogahed Fawzy Hussein Mogahed
Medical Parasitology Department, Faculty of Medicine, Alexandria University
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1995-7645.248341

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Objective: To assess the role of miRNA712_3p as a specific biomarker in early detection of toxoplasmosis in plasma of mice acutely infected with Toxoplasma gondii. Methods: Real-time PCR was used to measure the level of miRNA712_3p in plasma of infected mice. Immune-competent and immune-suppressed mice were examined, three and five days post-infection. Results: Results revealed significant up-regulation of plasma miRNA712_3p in both immune- competent and immune-compromised groups in comparison to the control non-infected group. Additionally, an increase in the level of miRNA712_3p was noticed correspondently in the parasite density detected in liver impression smears. Conclusions: miRNA712_3p can be used as a novel biomarker for the detection of Toxoplasma gondii infection in both immune-competent and immune-compromised host.

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